Vitamin D3 VitD insufficiency is postulated to represent a major modifiable risk factor for multiple sclerosis MS. While low VitD levels strongly correlate with higher MS risk in white populations, this is not the case for other ethnic groups, suggesting the existence of a genetic component. Moreover, VitD supplementation studies in MS so far have not shown a consistent benefit. We sought to determine whether direct manipulation of VitD levels modulates central nervous system autoimmune disease in a sex-by-genotype-dependent manner. To this end, we used a dietary model of VitD modulation, together with the autoimmune animal model of MS, experimental autoimmune encephalomyelitis EAE. EAE protection was accompanied by sex- and genotype-specific suppression of proinflammatory transcriptional programs in CD4 T effector cells, but not CD4 regulatory T cells.
“We Slept With Hundreds of People”: 3 Older Women on Sex and Pleasure
The best time of day to have sex, according to science
Goodbye coffee break, hello afternoon delight. Science has revealed many secrets over the years but this one may be the most stimulating. The best time of day to get busy is right around 3 p. While men may perform best physically in the early to mid-morning due to a testosterone boost , they hit an estrogen peak later in the afternoon, which makes them more emotionally attuned to their partners. Women experience a peak in cortisol levels right around then, which helps boost energy and alertness. Of course, same sex couples might have a different groove. But if 3 p.
When I was 11 years old, my mother silently snuck into my bedroom. Under the cover of midnight, she sat cross-legged at the end of my bed and proceeded to give me The Talk, although it was more of a whisper. Instead of focusing on the anatomy of sex — the biological prophecies by which, some say, our bodies were made to meld into one — my mother chose to emphasize pleasure. She spoke about the importance of passion: pursuing it, asking for it and finding it within yourself.
Fit for the show. Slim cutie pie on the. Legal age teenager stunner. Fresh faced coed spreads her. Her teasing is close to.